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Silydianin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Silydianin图片
CAS NO:29782-68-1
包装:20mg
市场价:1386元

产品介绍
水飞蓟素是水飞蓟的活性成分，具有抗胶原酶、抗肿瘤和抗弹性蛋白酶活性。 Silydianin 是一种天然蛋白质酪氨酸磷酸酶 1B (PTP1B)，IC50 为 17.38 μM。水飞蓟素对体外氧化产物的产生和释放具有抑制作用。
Cas No.29782-68-1
别名水飞蓟宁
Canonical SMILESCOC1=C(C=CC(=C1)C2C3COC4(C3C(=CC2C4=O)C5C(C(=O)C6=C(C=C(C=C6O5)O)O)O)O)O
分子式C25H22O10
分子量482.44
溶解度≥ 48.2mg/mL in DMSO
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 17.38 μM. Silydianin has inhibitory effect on the in vitro production and release of oxidative products[1][2][3].

References:
[1]. Vostálová J, et al. Skin Protective Activity of Silymarin and its Flavonolignans. Molecules. 2019 Mar 14;24(6).
[2]. Qin N, et al. Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1283-1291.
[3]. Zielińska-Przyjemska M, et al. An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species. Phytother Res. 2006 Feb;20(2):115-9.