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Monoamine Oxidase B inhibitor 1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Monoamine Oxidase B inhibitor 1图片
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Monoamine Oxidase B inhibitor 1 是一种有效、可逆，具有口服活性的和选择性的单胺氧化酶 B (MAO-B) 抑制剂，IC50为 0.02 nM。Monoamine Oxidase B inhibitor 1 具有抗氧化和抗神经炎症活性。Monoamine Oxidase B inhibitor 1 可以穿过血脑屏障 (BBB)，可用于帕金森病研究。
生物活性

Monoamine OxidaseB inhibitor 1 is a potent, reversible, orally active and selectivemonoamine oxidaseB (MAO-B)inhibitor with anIC50of 0.02 nM.Monoamine OxidaseB inhibitor 1 has antioxidant and anti-neuroinflammatory activities.Monoamine OxidaseB inhibitor 1 can across the blood-brain barrier (BBB), and can be used for Parkinson’s disease study[1].

IC50& Target[1]

MAO-B

0.02 nM (IC50)

MAO-A

810 nM (IC50)

体外研究
(In Vitro)

In cellular experiments, Monoamine Oxidase B inhibitor 1 (compound 14a; 0.5-10.0 μM) could significantly decrease the production of NO and TNF-α in LPS-stimulated BV-2 cells[1].

体内研究
(In Vivo)

In in vivo acute and subacute MPTP-induced mice model of Parkinson’s disease, Monoamine Oxidase B inhibitor 1 (compound 14a; 6-37.4 mg/kg; oral administration) could significantly improve most behavioral disorders, restore the dopamine content and decrease the MDA content in the mice striatum[1].

分子量

298.31

Formula

C18H15FO3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.