Neuroinflammatory-IN-2 is a potent anti-neuroinflammatory agent with anIC₅₀value of 10.30 μM forMAO-B, and 96.33% inhibition ofAβ_1-42aggregation at 25 μM. Neuroinflammatory-IN-2 has neuroprotective activity in H₂O₂-induced PC-12 cell injury. Neuroinflammatory-IN-2 also has biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. Neuroinflammatory-IN-2 can be used for researching Alzheimer’s disease^[1].

Neuroinflammatory-IN-2 (compound 7i) (1 and 10 μM) dramatically increases the viability of H₂O₂-treated PC-12 cells by 70.2% and 81.6% at 1 and 10 μM, respectively^[1].
Neuroinflammatory-IN-2 (0.5, 2.5 and 10.0 μM) inhibits NO expression in LPS-stimulated BV-2 cells by 32.4%, 46.7% and 57.2% at the concentration of 0.5, 2.5 and 10.0 μM respectively; and inhibits TNF-α by 35.8%, 53.1% and 76.5%, respectively^[1].

422.49

C₂₅H₂₇FN₂O₃

2361384-14-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.