| CAS NO: | 1135242-13-5 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 369.89 |
|---|---|
| Formula | C18H28ClN3O3 |
| CAS No. | 1135242-13-5 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: ≥ 33 mg/mL |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| SMILES | O=C(N1CCC(NCCNC(C2=CC=CC=C2C)=O)CC1)OCC.[H]Cl |
| Synonyms | CID 25010775, CID25010775, CID-25010775; VU0357017, VU-0357017, VU 0357017 |
| In Vitro | In vitro activity: VU0357017 is a M1-selective agonists that appear to activate M1 through actions at an allosteric site. Ki values of VU0357017 derived from competition binding experAiment is 9.91(rM1), 21.4 (rM2), 55.3 (rM3), 35 (rM4), and 50 (rM5), respectively.VU0357017 is a highly selective M1 agonist suggests that these compounds are unlikely to act at the highly conserved orthosteric site on M1 and are more likely to act as allosteric agonists. Kinase Assay: VU0357017 is a M1-selective agonists that appear to activate M1 through actions at an allosteric site. Ki values of VU0357017 derived from competition binding experiment is 9.91(rM1), 21.4 (rM2), 55.3 (rM3), 35 (rM4), and 50 (rM5), respectively. Cell Assay: |
|---|---|
| In Vivo | VU0357017 has robust efficacy in improving hippocampal-dependent learning in rats. VU0357017 enhances performance in Morris water maze and contextual fear conditioning in rats. |
| Animal model | Rats |
| Formulation & Dosage | |
| References | ACS Chem Neurosci. 2012 Dec 19;3(12):1025-36.ACS Chem Neurosci. 2010;1(2):104-121.J Neurosci. 2012 Jun 20;32(25):8532-44. Bioorg Med Chem Lett. 2013 Jan 1;23(1):223-7. |
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