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(±)-Cloprostenol sodium salt
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(±)-Cloprostenol sodium salt图片
CAS NO:55028-72-3
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
(±)-Cloprostenol sodium salt (ICI 80996 sodium salt) 是一种有效的合成前列腺素类似物，作为黄体溶解剂，是一种 PGF2α 受体激动剂。
Cas No.55028-72-3
别名氯前列烯醇纳; ICI 80996 sodium salt
化学名sodium (E)-7-((1R,2R,3S,5R)-2-((R,Z)-4-(3-chlorophenoxy)-3-hydroxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoate
Canonical SMILESClC1=CC(OC[C@@H](/C=C\[C@@H]([C@H]2O)[C@@H](C/C=C/CCCC([O-])=O)[C@@H](C2)O)O)=CC=C1.[Na+]
分子式C22H28ClNaO6
分子量446.9
溶解度DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件Desiccate at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cloprostenol sodium salt (ICI 80996 sodium salt) is a potent synthetic prostaglandin analogue, acts as a luteolytic agent[1], and is a PGF2α receptor agonist[2].

Cloprostenol is a PGF2α receptor agonist[2].Cloprostenol (0.1 μM) counteracts the adipogenic effects of statil, on both intracellular lipid accumulation and expression of transcripts for proadipogenic factors C/EBPα and PPARγ after treatment for 6 days[2].

Cloprostenol sodium salt (25 μg) decreases plasma progesterone in pregnant rats[1].

References:
[1]. Salazar H, et al. Luteolytic effects of a prostaglandin analogue, cloprostenol (ICI 80,996), in rats: ultrastructural and biochemical observations. Biol Reprod. 1976 May;14(4):458-72.
[2]. Pastel E, et al. Aldose reductases influence prostaglandin F2α levels and adipocyte differentiation in male mouse and human species. Endocrinology. 2015 May;156(5):1671-84.