4-PPBP maleate

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4-PPBP maleate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

201216-39-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

4-PPBP maleate 是一种有效的σ1受体配体和σ1受体激动剂。4-PPBP maleate 是一种非竞争性、选择性NR1a/2B NMDA受体 (在Xenopus oocytes表达) 拮抗剂。4-PPBP maleate 具有神经保护作用。

生物活性

4-PPBP maleate is a potentσ 1 receptorligand and agonist. 4-PPBP maleate is a non-competitive, selectiveNR1a/2B NMDA receptors(expressed inXenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection^[1]^[2]^[3].

体外研究
(In Vitro)

4-PPBP maleate elicits ERK1/2 phosphorylation in primary neurons^[3].

体内研究
(In Vivo)

4-PPBP maleate (1 μmol/kg; i.v.) decreases brain injury after transient focal ischemia in rats^[2].

Animal Model:	Male rats weighing 300 to 385 g (Transient focal ischemia model)^[2]
Dosage:	1 μmol/kg
Administration:	Per hour by continuous intravenous infusion starting 1 hour after the initiation of ischemia and continuing through 22 hours of reperfusion.
Result:	Decreased brain injury after transient focal ischemia in rats.

分子量

409.52

Formula

C₂₅H₃₁NO₄

CAS 号

201216-39-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.