VEGFR-2-IN-11 (Compound 8h) 是一个有效的VEGFR-2抑制剂，其IC50值为 60.27 nM。VEGFR-2-IN-11 表现出抗癌活性，诱导细胞凋亡 (apoptosis)。
| 生物活性 | VEGFR-2-IN-11 (Compound 8h) is a potentVEGFR-2inhibitor with anIC50of 60.27 nM. VEGFR-2-IN-11 shows antitumor activity and induces cellapoptosis[1]. |
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体外研究
(In Vitro) | VEGFR-2-IN-11 (Compound 8h) (0-100 μM) shows antiproliferation activities against tumor cells and induces a low toxic effect in normal cells[1].
VEGFR-2-IN-11 (4.92 μM, 24h) arrests the cell cycle on MCF-7 at a G1/S phase and induces MCF-7 cell apoptosis[1].
Cell Proliferation Assay[1] | Cell Line: | HCT-116, HEPG-2, and MCF-7 | | Concentration: | 0-100 μM | | Incubation Time: | | | Result: | Showed antiproliferation activities with IC50values of 8.62 ± 0.7, 10.18 ± 0.8, and 4.92 ± 0.2 μM against HCT-116, HEPG-2, and MCF-7 cells, respectively. |
Cell Cycle Analysis[1] | Cell Line: | MCF-7 | | Concentration: | 4.92 μM | | Incubation Time: | 24 h | | Result: | Resulted in a significant increase in the ratio of MCF-7 cells in the G0/G1 phase from 45.81 % (untreated cells) to 49.18 % and the S phase from 39.14% (untreated cells) to 43.22% with a concomitant decrease in the number of cells in G2/M phase by 7.6% compared to untreated control (15.05%). |
Apoptosis Analysis[1] | Cell Line: | MCF-7 | | Concentration: | 4.92 μM | | Incubation Time: | 24 h | | Result: | Induced the early apoptosis in MCF-7 (3.46%) 6.4 folds over the untreated cells (0.54%). Enhanced the late apoptotic induction by 20.72% compared to untreated control (0.18%). Induced total apoptosis with 36.24%. |
Cell Cytotoxicity Assay[1] | Cell Line: | WI-38 | | Concentration: | 0-100 μM | | Incubation Time: | | | Result: | Induced a low toxic effect with an IC50value of 44.45 ± 3.2 μM against WI-38 cells. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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