VEGFR-2-IN-23

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VEGFR-2-IN-23

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2411174-53-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

VEGFR-2-IN-23 (compound 11b) 是一种有效的选择性VEGFR-2抑制剂，IC₅₀值为 0.34 nM。VEGFR-2-IN-23 显示出抗肿瘤活性。VEGFR-2-IN-23 诱导细胞凋亡 (apoptosis) 和 MCF-7 细胞停滞在 G1 期。

生物活性

VEGFR-2-IN-23 (compound 11b) is a potent and selectiveVEGFR-2inhibitor with anIC₅₀value of 0.34 nM. VEGFR-2-IN-23 shows antitumor activity. VEGFR-2-IN-23 inducesapoptosisand cell cycle arrest at G1 phase^[1].

IC₅₀& Target^[1]

VEGFR-2

0.19 nM (IC₅₀)

体外研究
(In Vitro)

VEGFR-2-IN-23 (compound 11b) shows antitumor activity with IC₅₀s of 23, 0.8, 1.3, 46 nM for PC3, DU145, MCF-7, MDA-MB435 cells, respectively^[1].

体内研究
(In Vivo)

VEGFR-2-IN-23 (5, 10 mg/kg; i.p.) shows inhibits the tumor growth in MCF-7 xenograft tumor models^[1].

分子量

381.39

Formula

C₂₂H₁₅N₅O₂

CAS 号

2411174-53-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.