Betaine chloride

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Betaine chloride

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

590-46-5

包装与价格：

包装	价格(元)
500mg	电议
1 g	电议
5 g	电议

产品名称

盐酸甜菜碱

产品介绍

Betaine hydrochloride 是许多食物中发现的天然化合物，也是一种可维持正常 DNA 甲基化模式的活性甲基供体。

生物活性

Betaine hydrochloride is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns.

IC₅₀& Target

Microbial Metabolite

体外研究
(In Vitro)

It is found that proliferation of HeLa cells is inhibited significantly upon exposure to increasing Betaine hydrochloride levels with the MTT test (p<0.05). The percentage of S phase cells in the low dose groups (<5 mgml) are distinctly higher than in high dose groups, and the rates of sub-g1 phase opposite (p<0.05). a concentration betaine hydrochloride (>5.0 mg/mL) significantly promotes the apoptosis of HeLa cells (p<0.01). SOD activities of the low dose groups are slightly higher than the control group (p<0.05), and there are obvious synchronicity and correlation among the expression of promoting apoptosis genes Bax, P53, Caspase 3 and apoptosis suppression gene Bcl-2. In response to an apoptosis-inducing stimulus, p53 and cyclin D1 can be activated with blockage of the cell cycle at G1/S or S/G2 checkpoints^[1].

体内研究
(In Vivo)

Liver-to-body weight ratio is attenuated by Betaine hydrochloride supplementation. When Betaine hydrochloride is added to the alcohol-containing liquid diet, both hepatic triglyceride (TG) accumulation and liver injury are significantly reduced. Betaine hydrochloride supplementation attenuates epididymal fat pad mass loss induced by chronic alcohol feeding. Betaine hydrochloride supplementation prevents the depletion of S-adenosylhomocysteine (SAM) and reduces the increase in S-adenosylhomocysteine (SAH), thereby improving the methylation state of the adipose tissue^[2].

分子量

153.61

性状

Solid

Formula

C₅H₁₂ClNO₂

CAS 号

590-46-5

中文名称

盐酸甜菜碱；甜菜碱盐酸盐

结构分类

Ketones, Aldehydes, Acids

来源

Plants
Chenopodiaceae
Beta vulgarisLinn.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 100 mg/mL(651.00 mM;Need ultrasonic)

DMSO : 5 mg/mL(32.55 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	6.5100 mL	32.5500 mL	65.0999 mL
5 mM	1.3020 mL	6.5100 mL	13.0200 mL
10 mM	0.6510 mL	3.2550 mL	6.5100 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。