Escin IIa, isolated from horse chestnut, the seeds ofAesculus hippocastanumL., has positive effects on acute inflammation inanimals. Escin IIa has gastroprotections on ethanol-induced gastric mucosal lesions in rats^[1][2].

Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibits the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest^[1].
Escin IIa (10-50 mg/kg;p.o.;) potently inhibits ethanol-induced gastric mucosal lesions^[2].

1101.23

C₅₄H₈₄O₂₃

158732-55-9

• Terpenoids
• Triterpenes

• Plants
• Hippocastanaceae
• Aesculus hippocastanum

• Plants
• other families

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.