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UK 14,304
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
UK 14,304图片
CAS NO:59803-98-4
包装:1mg
市场价:1218元

产品介绍
UK 14,304 (UK 14304) 是一种完整的 α2-肾上腺素受体 (⋱2-AR) 激动剂。
Cas No.59803-98-4
别名溴莫尼定; UK 14304; AGN190342
化学名5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine
Canonical SMILESBrC1=C(NC2=NCCN2)C=CC3=C1N=CC=N3
分子式C11H10BrN5
分子量292.13
溶解度DMF: 1 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

[3H]Brimonidine (UK 14304) is a full agonist at alpha 2-adrenergic receptors. [3H]Brimonidine (UK 14304) labels at least 2 specific binding sites in human brain that both have the characteristics of an alpha 2-adrenergic binding site. GTP decreases agonist binding at both of these sites, but with different potencies at each site [1-3].

References:
[1]. Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci, 1988. 43(22): p. 1805-12.
[2]. Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol, 1981. 72(4): p. 413-5.
[3]. Chopin, P., F.C. Colpaert, and M. Marien, Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther, 1999. 288(2): p. 798-804.