您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Tropicamide
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Tropicamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tropicamide图片
CAS NO:1508-75-4
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
Tropicamide (Ro 1-7683) 是一种选择性 M4 毒蕈碱乙酰胆碱受体拮抗剂。
Cas No.1508-75-4
别名托吡卡胺; Ro 1-7683
化学名N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide
Canonical SMILESCCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2
分子式C17H20N2O2
分子量284.35
溶解度≥ 14.2mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist .Target: mAChRTropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. It is used to allow better examination of the lens, vitreous humor, and retina. Due to its relatively short duration of effect (4-8 hours), it is typically used during eye examinations such as the dilated fundus examination, but it may also be used before or after eye surgery. Cycloplegic drops are often also used to treat anterior uveitis, decreasing risk of posterior synechiae and decreasing inflammation in the anterior chamber of the eye [1-3].

References:
[1]. Lazareno, S., N.J. Buckley, and F.F. Roberts, Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Mol Pharmacol, 1990. 38(6): p. 805-15.
[2]. Hernandez, M., et al., Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. Br J Pharmacol, 1993. 110(4): p. 1413-20.