您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Xylazine HCl
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Xylazine HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Xylazine HCl图片
CAS NO:23076-35-9
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
100mg电议
500mg电议

产品介绍
α2 Adrenoceptor agonist
Cas No.23076-35-9
别名盐酸甲苯噻嗪,BAY 1470 hydrochloride
化学名N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine;hydrochloride
Canonical SMILESCC1=C(C(=CC=C1)C)NC2=NCCCS2.Cl
分子式C12H16N2S.HCl
分子量256.79
溶解度≥ 12.8395mg/mL in DMSO, ≥ 50 mg/ml in Water
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Xylazine HCl is a strong agonist of α2-adrenoceptor [1].

Xylazine HCl has been reported to stimulate the proliferation of rat thymocytes in vivo (at doses of 2.5 mg/kg and 5 mg/kg) and in vitro (at concentration of 5 mM) [2]. In the analgesic testing, Xylazine has shown a significant prolongation of the analgesic effects in the presence of naloxine in 40 and 50 mins. In addition, Xylazine has also shown the inhibitory effect in the mouse vas deferens bioassay with the IC50 value of 18nM. Furthermore, Xylazine has displayed a potent specific [3H]-dihydromorphine binding inhibition with the IC50 value of 8μM in opiate receptor binding test [1].

References:
[1] S.  BROWNING, D.LAWRENCE1, A.LIVINGSTON & B.MORRIS. Interaction of drugs active at opiate receptors and drugs active at α2-adrenoceptors on various test systems
[2] Colic M1, Cupic V, Pavicic L, Vucevic D, Varagic VM.  Xylazine, an alpha 2-adrenergic agonist, modulates proliferation of rat thymocytes in vivo and in vitro. Methods Find Exp Clin Pharmacol. 2000 Sep;22(7):557-62.