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Telratolimod(MEDI 9197)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Telratolimod(MEDI 9197)图片
CAS NO:1359993-59-1
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Telratolimod (MEDI 9197) (MEDI9197) 是一种有效的 toll 样受体 7/8 (TLR7/8) 激动剂，具有抗肿瘤活性。
Cas No.1359993-59-1
别名MEDI9197; 3M-052
Canonical SMILESNC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3OCCCCNC(CCCCCCCCCCCCCCCCC)=O
分子式C36H59N5O2
分子量593.89
溶解度DMSO : 5 mg/mL (8.42 mM);Water :< 0.1 mg/mL (insoluble)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

Telratolimod is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity.

Telratolimod (3M-052) is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity[1].

Telratolimod (50 μg) inhibits the tumor volume, and more potently blocks tumor gowth in combination with CpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 μg) plus 200 μg of CpG ODN slows tumor growth and prolongs survival of mice bearing large tumors[1].

[1]. Zhao BG, et al. Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors. J Immunother Cancer. 2014 May 13;2:12.