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Lofepramine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Lofepramine图片
CAS NO:23047-25-8
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
Lofepramine (Lopramine) 是一种有效的三环类抗抑郁药，可广泛代谢为地西帕明。
Cas No.23047-25-8
别名洛非帕明,Lopramine
化学名1-(4-chlorophenyl)-2-((3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)(methyl)amino)ethanone
Canonical SMILESClC1=CC=C(C=C1)C(CN(C)CCCN2C3=CC=CC=C3CCC4=CC=CC=C24)=O
分子式C26H27N2OCl
分子量418.97
溶解度3mg/mL in DMSO, 10mg/mL in DMF
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lofepramine is a first generation tricyclic antidepressant that is extensively metabolized to desipramine.[1] It potently inhibits serotonin and norepinephrine transporters (Kds = 70 and 5.4 nM, respectively) and less potently antagonizes serotonin, histamine, and muscarinic receptors.[2],[3],[4]

Reference:
[1]. Lancaster, S.G., and Gonzalez, J.P. Lofepramine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs 37(2), 123-140 (1989).
[2]. Tatsumi, M., Groshan, K., Blakely, R.D., et al. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur. J. Pharmacol. 340(2-3), 249-258 (1997).
[3]. Cusack, B., Nelson, A., and Richelson, E. Binding of antidepressants to human brain receptors: Focus on newer generation compounds. Psychopharmacology (Berl.) 114(4), 559-565 (1994).
[4]. Stanton, T., Bolden-Watson, C., Cusack, B., et al. Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminics. Biochem. Pharmacol. 45(11), 2352-2354 (1993).