Taccalonolide E 是一种微管稳定剂，诱导癌细胞凋亡 (apoptosis)。
| 生物活性 | Taccalonolide E is a microtubule stabilizer and inducescancercellapoptosis. |
体外研究
(In Vitro) | Taccalonolide E (5 or 10 μM; 18 h) 在 A-10 细胞中导致间期细胞中细胞微管密度增加，形成厚束微管[1]。
Taccalonolide E (1 or 5 μM; 18 h) 导致 A-10 和 HeLa 细胞出现异常多极有丝分裂纺锤体[1]。
Taccalonolide E (5 μM; 6-24 h) 在 G2-M 期阻滞细胞周期[1]。
Taccalonolide E (0.5-5 μM; 18 h) 在间期细胞中启动微核化[1]。
Taccalonolide E (48 h) 抑制癌细胞增殖[1]。
Taccalonolide E (10 μM; 1 h) 导致 MDA-MB-435 细胞微管蛋白聚合[1]。
Taccalonolide E (5 μM; 4-30 h) 启动 Bcl-2 磷酸化，MAPK 激活和凋亡[1]。
Cell Cycle Analysis[1] | Cell Line: | MDA-MB-435 cells | | Concentration: | 5 μM | | Incubation Time: | 6, 12, 18, or 24 h | | Result: | Caused cells to accumulate in the G2-M phase of the cell cycle. |
Cell Proliferation Assay[1] | Cell Line: | SK-OV-3, MDA-MB-435, NCI/ADR, 1 A9, PTX 10, PTX 22 and 1A9/A8 cells | | Concentration: | | | Incubation Time: | 48 h | | Result: | Inhibited the proliferation with IC50s of 0.99 ± 0.08, 0.78 ± 0.17, 21.1 ± 0.46, 0.34 ± 0.04, 1.64 ± 0.25, 4.01 ± 0.20 and 1.42 ± 0.30 μM against SK-OV-3, MDA-MB-435, NCI/ADR, 1 A9, PTX 10, PTX 22 and 1A9/A8 cells, respectively. |
Western Blot Analysis[1] | Cell Line: | MDA-MB-435 cells | | Concentration: | 5 μM | | Incubation Time: | 4, 6, 12, 24, or 30 h | | Result: | Activated ERK1/2 and increased PARP cleavage. |
|
| 分子量 | |
| Formula | |
| CAS 号 | |
| 中文名称 | |
| 结构分类 | |
| 来源 | - Plants
- Taccaceae
- Tacca chantrieriAndre
|
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
m.cnreagent.com