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Ro 90-7501
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ro 90-7501图片
CAS NO:293762-45-5
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Ro 90-7501 是一种淀粉样蛋白 β42 (Aβ42) 原纤维组装抑制剂，可降低 Aβ42 诱导的细胞毒性（EC50 为 2 μM）。
Cas No.293762-45-5
化学名2'-(4-aminophenyl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-6-amine
Canonical SMILESNC1=CC=C2N=C(C3=CC=C4N=C(C(C=C5)=CC=C5N)NC4=C3)NC2=C1
分子式C20H16N6
分子量340.39
溶解度15 mg/ml in DMF, 10 mg/ml in DMSO, 2 mg/ml in Ethanol
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ro 90-7501 is a bi-benzimidazole compound that was first found to retard the formation of mature amyloid β42 fibrils in a cell-based assay.[1] Instead, extended polymeric sheets and fibrillary intermediates of amyloid β42 accumulated in response to Ro 90-7501 treatment, resulting in reduced cytotoxicity (EC50 = 2 μM).1 More recently, Ro 90-7501 was shown to modulate signaling in cells stimulated with polyinosinic-polycytidylic acid (poly(I:C); a toll-like receptor 3 (TLR3), and RIG-1-like receptor agonist.[2] Ro 90-7501 (10 μM) enhanced poly(I:C)-induced IFN-β expression, decreased NF-κB activation, and amplified the suppression of vesiculastomatitis virus replication by poly(I:C) in HEK293 cells expressing TLR3.[2]

Reference
[1]. Bohrmann, B., Adrian, M., Dubochet, J., et al. Self-assembly ofβamyloid 42 is retarded by small molecular ligands at the stage of structural intermediates. Journal of Structural Biology 130(2-3), 232-246 (2000).
[2]. Guo, F., Mead, J., Aliya, N., et al. RO 90-7501 enhances TLR3 and RLR agonist induced antiviral response. PLoS One 7(10), (2012).