Complanatoside A is a flavonol glycoside isolated fromAstragalus complanatus, and currently it is used as a quality control index forA. complanatusin the 2010 edition of theChinese Pharmacopoeia.

A simple and sensitive LC-MS/MS method is developed for the determination of complanatoside A in rat plasma over the range of 2.3–575 ng/mL. Complanatoside A is extracted from plasma by a protein precipitation procedure, separated by LC and detected by MS/MS in positive electrospray ionization mode. The lower limit of quantification is established at 2.3 ng/mL. Intra- and inter-day precisions (LLOQ, low-QC, med-QC and high-QC) are less than 7.9%, and accuracies are between 94.0 and 105.1%. Matrix effect is acceptable (97.9–103.0%) and extraction recovery is reproducible (88.5–94.4%). Complanatoside A is stable in the investigated conditions. The method is applied to the pharmacokinetics of complanatoside A in rats^[1].

642.52

C₂₇H₃₀O₁₈

146501-37-3

沙苑子苷 A

• Flavonoids
• Flavonols

• Phenols
• Polyphenols

• Plants
• Papilionaceae
• Astragalus complanatus

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

DMSO : ≥ 35.7 mg/mL(55.56 mM)

*"≥" means soluble, but saturation unknown.