Aeroplysinin 1 ((+)-Aeroplysinin-1)，从海洋海绵中分离出的次生代谢产物，对革兰氏阳性细菌 (bacteria) 显示出有效的抗生素作用，并具有针对HIV-1的抗病毒活性 (IC50=14.6 μM)。Aeroplysinin 1 具有抗炎，抗血管生成和抗肿瘤活性。Aeroplysinin 1诱导内皮细胞凋亡 (apoptosis)。
| 生物活性 | Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potentantibioticeffects on Gram-positivebacteriaand exerts antiviral activity againstHIV-1(IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 inducesapoptosisin endothelial cells[1][2]. |
| IC50& Target[1] | HIV-1 | Bacterial | HIV-1 14.6 μM (IC50) | Apoptosis |
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体外研究
(In Vitro) | Aeroplysinin 1 shows anti-proliferative effect against tumor cells (HT-1080, HTC-116, HeLa, THP-1, NOMO-1 and HL-60 cells), with IC50s ranging from 2.3 to 17 μM[1].
Aeroplysinin-1 also exhibits an antiviral activity toward HIV-1 caused by inhibition of its reverse transcriptase activity[1].Aeroplysinin 1 inhibitsP. phosphoreum,C. wailesii,P. minimumand HIV with IC50s of 3.5, 5.6, 7.0 and 14.6 μM[1].Aeroplysinin 1 inhibits human endothelial cells (EVLC-2, HMEC, RF-24, and HUVEC cells), with IC50s ranging from 2.6 to 4.7 μM[2].
(+)-Aeroplysinin-1 (0.25-0.5 μM) blocks the EGF-dependent proliferation of both MCF-7 and ZR-75-1 human breast cancer cells and inhibits the ligand-induced endocytosis of the EGF receptor in vitro[3].
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| 结构分类 | - Antibiotics
- Other Antibiotics
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Pure form | -20°C | 3 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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