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Tenacissoside H
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tenacissoside H图片
CAS NO:191729-45-0
包装:20mg
市场价:3318元

产品介绍
Tenacissoside H 是从 Caulis Marsdeniae Tenacissimae 中提取的中药单体。
Cas No.191729-45-0
别名通关藤苷H,Tenacissimoside C
Canonical SMILESCCC(C(O[C@@]([C@](OC(C)=O)([H])[C@]12C)([H])[C@]3([H])[C@]4(CC[C@@](O[C@@]5([H])C[C@](OC)([H])[C@@](O[C@@]6([H])[C@@](O)([H])[C@@](OC)([H])[C@@](O)([H])[C@@](O6)([H])C)([H])[C@@](O5)([H])C)([H])C[C@]4([H])CC[C@@]3(O7)[C@@]27CC[C@@]1([H])C(C)=O)C)=O)([H])C
分子式C42H66O14
分子量794.96
溶解度≥ 74.4mg/mL in DMSO
储存条件4°C, away from moisture and light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tenacissoside H is a Chinese medicine monomer extracted, isolated from Caulis Marsdeniae Tenacissimae.IC50 value:Target:In vitro: TDH significantly inhibited cells proliferation in a time-and-dose-dependent manner. TDH arrested the cell cycle in S phase and significantly inhibited PI3K and NF-κB mRNA expression, compared with blank controlled group (P< 0.05). [1]In vivo: TDH strongly inhibits tumor growth and volume. PCNA expression was significantly decreased after treatment of TDH. TDH downregulated proteins expression in PI3K/Akt-NF-κB transduction cascade (P< 0.05). [1]

References:
[1]. Jia YS, et al. Antitumor Activity of Tenacissoside H on Esophageal Cancer through Arresting Cell Cycle and Regulating PI3K/Akt-NF-κB Transduction Cascade. Evid Based Complement Alternat Med. 2015;2015:464937.