由 Albophoma yamanashiensis 生产的三萜 C 显示出对酰基辅酶 A:胆固醇酰基转移酶 (ACAT) 的有效抑制活性。
| Cas No. | 156967-65-6 |
| 别名 | 1,4A,4B,6,7,7A,8,13,13B,13C,14,15,15A,16A-十四氢-1,1,13B,13C-四甲基-3-(2-甲基-1-丙烯基)-5BH-[1,3]二恶英并[5'',4'':2',3']环氧乙烷并[4',4'A][1]苯并吡喃并[5',6':6,7]茚并[1,2-B]吲哚-5B-醇 |
| Canonical SMILES | C/C(C)=C/[C@@H]1OC(C)(C)[C@@]2([H])O[C@@]3([H])CC[C@@]4(C)[C@](CC[C@]5([H])[C@]4(C)C6=C(C(C=CC=C7)=C7N6)C5)(O)[C@@]3(O8)[C@H]8[C@]2([H])O1 |
| 分子式 | C32H41NO5 |
| 分子量 | 519.7 |
| 溶解度 | DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Terpendole C is an indole diterpene alkaloid fungal metabolite originally isolated from A. yamanashiensis and an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 2.1 μM in rat liver microsomes). It also inhibits ACAT in J774 macrophages (IC50 = 0.46 μM) without affecting cell growth. |
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