CAS NO: | 1926986-36-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factorTFIIDsubunit 1 and transcription-initiation-factorTFIIDsubunit 1-like, with anIC50of 10 nM for TAF1(2). | ||||||||||||||||
IC50& Target | IC50: 10 nM (TAF1(2))[1]. | ||||||||||||||||
体外研究 (In Vitro) | GNE-371 (compound 27) binds TAF1(2) with an IC50of 10 nM while maintaining excellent selectivity over other bromodomain-family members. GNE-371 is also active in a cellular-TAF1(2) target-engagement assay (IC50=38 nM) and exhibits anti-proliferative synergy with the BET inhibitor JQ1, suggesting engagement of endogenous TAF1 by GNE-371 and further supporting the use of GNE-371 in mechanistic and target-validation studies[1]. | ||||||||||||||||
分子量 | 431.49 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C24H25N5O3 | ||||||||||||||||
CAS 号 | 1926986-36-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, protect from light, stored under argon *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under argon) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 50 mg/mL(115.88 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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