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Perindopril
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Perindopril图片
CAS NO:82834-16-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
Perindopril (S-9490) 是一种长效 ACE 抑制剂,用于治疗高血压、心力衰竭或稳定型冠状动脉疾病。
Cas No.82834-16-0
别名培哚普利; S-9490
化学名(2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
Canonical SMILESCCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O
分子式C19H32N2O5
分子量368.47
溶解度Ethanol: 25 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Perindopril is an inhibitor of angiotensin-I converting enzyme (ACE) [1].

As an inhibitor of ACE, perindopril has been reported to have anticancer activity through the inhibition of tumor growth and angiogenesis in hepatocellular carcinoma cells. In the in vitro cell proliferation assays, perindopril does not show significant effect on the cell proliferation. However, even 1μM perindoprilat can significantly reduce mRNA expression of VEGF and can inhibit the induction activity of the VEGF promoter in KB cells. Also in KB cells, 1μM perindoprilat treatment significantly suppresses the angiotensin II production. Besides that, In vivo assays demonstrate perindopril can suppress the growth of SCC-VII cells [1]. Moreover, it is reported that 8 mg perindopril given orally can lower blood pressure without a change in heart rate [1, 2].

References:
[1] Ryuji Yasumatsu, Torahiko Nakashima, Muneyuki Masuda, Aya Ito, Yuichiro Kuratomi, Yuichiro Kuratomi and Shizuo Komune. Effects of the angiotensin-I converting enzyme inhibitor perindopril on tumor growth and angiogenesis in head and neck squamous cell carcinoma cells. J Cancer Res Clin Oncol. 2004, 130: 567–573.
[2] A.A.Ajayi, K.R.Lees and J.L.Reid. Effects of angiotensin converting enzyme inhibitor, perindopril, on autonomic reflexes. Eur J Clin Pharmacol. 1986, 30:177-182.