| CAS NO: | 926259-99-6 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Molecular Weight (MW) | 214.22 |
|---|---|
| Formula | C11H10N4O |
| CAS No. | 926259-99-6 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 42 mg/mL (196.1 mM) |
| Water: <1 mg/mL | |
| Ethanol: 2 mg/mL warmed (9.3 mM) | |
| Other info | Chemical Name: N-(2-Aminophenyl)pyrazine-2-carboxamide; BG45 InChi Key: LMWPVSNHKACEKW-UHFFFAOYSA-N InChi Code: InChI=1S/C11H10N4O/c12-8-3-1-2-4-9(8)15-11(16)10-7-13-5-6-14-10/h1-7H,12H2,(H,15,16) SMILES Code: O=C(C1=NC=CN=C1)NC2=CC=CC=C2N |
| Synonyms | BG45; BG-45; BG 45 |
| In Vitro | In vitro activity: BG45 causes significant cell growth inhibition and induces caspase-dependent apoptosis in a series of MM cells. In RPMI8226 cells, BG45 synergistically enhances bortezomib-induced cytotoxicity. Cell Assay: The growth inhibitory effects of BG45 in MM cell lines are assessed by measuring 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrasodium bromide (MTT) dye absorbance. To measure proliferation of MM cells, the rate of DNA synthesis is measured by [3H]thymidine uptake. Cell lines: MM.1S, RPMI8226, U266, H929, MM.1 R, RPMI-LR5, OPM1, OPM2 and RPMI-DOX40 cells. |
|---|---|
| In Vivo | In mice bearing MM.1S xenograft of human MM, BG45 (50 mg/kg, i.p.) significantly inhibits MM tumor growth. When in combination with bortezomib, BG45 (50 mg/kg, i.p.) enhances bortezomib-induced cytotoxicity. |
| Animal model | Mice bearing MM.1S xenograft |
| Formulation & Dosage | Dissolved in 10% dimethylacetamide in 10% Kolliphor HS15 in PBS; 50 mg/kg, 5 days a week; i.p. injection |
| References | Leukemia. 2014 Mar;28(3):680-9. |
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