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Cefazolin sodium pentahydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cefazolin sodium pentahydrate图片
CAS NO:115850-11-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Cephazolin sodium pentahydrate
产品介绍
Cefazolin sodium pentahydrate 是第一代头孢菌素类抗生素,可用于多种细菌感染的研究。Cefazolin sodium pentahydrate 具有抗炎作用,可以减轻术后认知功能障碍 (POCD)。
生物活性

Cefazolin sodium pentahydrate is a first-generationcephalosporinantibioticand can be used in varieties ofbacterialinfections research[1]. Cefazolin sodium pentahydrate has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD)[2].

体外研究
(In Vitro)

Cefazolin sodium pentahydrate (0-300 μg/ml; 6 or 24 h) has a direct anti-inflammatory effect on C8-B4 cells stimulated by lipopolysaccharide[2].
Cefazolin sodium pentahydrate (0-400 μM; 72 h) treatment inhibits IL-2, IL-4 and IL-15-induced cell proliferation[3].
Cefazolin sodium pentahydrate (0-400 μM; 30 min) treatment inhibits IL-2, IL-4, IL-15 and IL-21-stimulated JAK3 phosphorylation[3].

Cell Viability Assay[2]

Cell Line:C8-B4 cells
Concentration:0, 50, 100, 150, 200, 250, or 300 μg/ml
Incubation Time:6 or 24 hours
Result:Inhibited the increase of IL-1β at all doses, but inhibited the increase of IL-6 only at 200 μg/ml.

Cell Proliferation Assay[3]

Cell Line:PBMC, and TF-1 cells
Concentration:0, 100, 200, and 400 μM
Incubation Time:72 hours
Result:Reduced IL-2, IL-4 and IL-15-induced cell proliferation, suggested that Cefazolin interferes not only with IL-15Rα, but also with IL-2/IL-15Rβ and/or γc.

Western Blot Analysis[3]

Cell Line:PBMC, NK-92, and TF-1 cells
Concentration:0, 100, 200, and 400 μM
Incubation Time:30 min
Result:Diminished the phosphorylation of JAK3 in response to the cytokine treatment, concluded suppressing signal transduction by γcreceptors.
体内研究
(In Vivo)

Cefazolin sodium pentahydrate (Subcutaneous injection; 300-500 mg/kg; once daily; 5 d) treatment improves learning and memory in mice after surgery[2].

Animal Model:6- to 8-week-old male CD-1 mice underwent clinical exploratory laparotomy[2]
Dosage:300-500 mg/kg
Administration:Subcutaneous injection; 300-500 mg/kg; once daily; 5 days
Result:Attenuated learning and memory dysfunction induced by the surgery.
Clinical Trial
分子量

566.57

Formula

C14H23N8NaO9S3

CAS 号

115850-11-8

中文名称

头孢唑啉五水合钠

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.