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Curvularin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Curvularin图片
CAS NO:10140-70-2
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
Curvularin 是一种真菌代谢物，是一种从新月弯孢菌中天然分离的强效霉菌毒素，可抑制细胞因子诱导的一氧化氮合酶 (iNOS)，IC50 为 9.5 μM。
Cas No.10140-70-2
别名弯孢霉菌素,(S)-Curvularin
化学名(4S)-4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-2H-3-benzoxacyclododecin-2,10(1H)-dione
Canonical SMILESO=C(CCCCC[C@H](C)O1)C(C(O)=CC(O)=C2)=C2CC1=O
分子式C16H20O5
分子量292.3
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml,Ethanol: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 μM[1][2].

References:
[1]. Kumar CG, et al. Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India. Springerplus. 2013 Dec;2(1):122.
[2]. Yao Y, et al. Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Mol Pharmacol. 2003 Feb;63(2):383-91.