Antimicrobial agent-8 (Compound 15) 是一种有效的抗菌剂，对革兰氏阴性和革兰氏阳性菌表现出强大的抗菌活性，MIC 范围为 2-8 μg/mL。Antimicrobial agent-8 对脂多糖引起的炎症表现出抗炎活性。
| 生物活性 | Antimicrobial agent-8 (Compound 15) is a potentantimicrobial agent, and shows potent antimicrobial activity with anMICrange of 2-8 μg/mL against Gram-negative and Gram-positive bacteria. Antimicrobial agent-8 shows anti-inflammatory activity against lipopolysaccharide-induced inflammation. |
体外研究
(In Vitro) | Antimicrobial agent-8 (2.8-56.4 μM; 24 h) inhibits Gram-negative bacteria and Gram-positive bacteria growth[1].
Antimicrobial agent-8 (5 and 20 μg/mL; 18 h) inhibits the production of nitric oxide (NO) and tumor necrosis factor-α (TNF-α) by lipopolysaccharide-stimulated in RAW 264.7 cells[1].
Antimicrobial agent-8 (1-32 μg/mL, 16 h; 8-128 μg/mL; 24 h) shows potent biofilm inhibitory (MBIC50=1 μg/mL) and eradicating activities (MBEC50=8 μg/mL) by MDRPA bacteria[1].
Antimicrobial agent-8 exhibits proteolytic resistance and salt/serum stability[1].
Antimicrobial agent-8 displays synergistic or additive effects when combined with selected clinically used antibiotics[1].
Cell Viability Assay[1] | Cell Line: | E. coli[KCTC 1682],P. aeruginosa[KCTC 1637],S. epidermidis[KCTC 1917] andS. aureus[KCTC1621] | | Concentration: | 2.8-56.4 μM | | Incubation Time: | 24 hours | | Result: | Inhibited Gram-negative bacteria with MIC values of 5.4 μM forE. coli[KCTC 1682] andP. aeruginosa[KCTC 1637].
Inhibited Gram- positive bacteria with MIC values of 2.7 μM and 5.4 μM forS. epidermidis[KCTC 1917] andS. aureus[KCTC1621], respectively. |
Cell Viability Assay[1] | Cell Line: | RAW 264.7 macrophages | | Concentration: | 5 and 20 μg/mL | | Incubation Time: | 18 hours | | Result: | Observed LPS-stimulated production of NO with an inhibitory rate of 90.79% at 5 μg/mL.
Exhibited inhibitory effects on the LPS-stimulated production of TNF-α with an inhibitory rate of 95.4% at 20 μg/mL. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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