CAS NO: | 376382-11-5 |
包装 | 价格(元) |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | BRD7389 is a specificRSKfamily kinase inhibitor withIC50s of 1.5 μM, 2.4 μM, and 1.2 μM forRSK1,RSK2, andRSK3, respectively. BRD7389 is a small-molecule inducer ofinsulinexpression in pancreatic α-cells[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | BRD7389 (0.425-6.8 μM) induces insulin expression in mouse α-cells after 3 days treatment. BRD7389 induces a dose-dependent up-regulation of insulin (Ins2) mRNA, peaking at 0.85 μM; 5 days treatment with BRD7389 results in greater induction of insulin gene expression, about 50-fold at 0.85 μM[1]. RT-PCR[1]
Cell Proliferation Assay[2]
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分子量 | 366.41 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C24H18N2O2 | ||||||||||||||||
CAS 号 | 376382-11-5 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 20.83 mg/mL(56.85 mM;ultrasonic and warming and heat to 60℃) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |