Cyproheptadine

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Cyproheptadine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

129-03-3

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议

产品介绍

Cyproheptadine 是一种有效的口服活性5-HT_2A受体拮抗剂，具有抗抑郁和抗血清素作用。Cyproheptadine 具有抗血小板活性。Cyproheptadine 可以用于血栓栓塞性疾病的研究。

生物活性

Cyproheptadine is a potent and orally active5-HT_2Areceptorantagonist, with antidepressant and antiserotonergic effects. Cyproheptadine has antiplatelet and thromboprotective activities. Cyproheptadine can be used for the research of thromboembolic disorders^[1]^[2].

体外研究
(In Vitro)

Cyproheptadine (0.01-100 nM; 1 minute) dose-dependently inhibits serotonin-enhanced ADP-induced mouse platelet aggregation in vitro^[2].
Cyproheptadine (10 nM) has the ability to inhibit 15 μM serotonin-enhanced ADP-induced (1 μM) tyrosine phosphorylation in platelets in vitro^[2].
Cyproheptadine inhibits human platelet PS exposure (Annexin V), P-selectin, and GPIIb-IIIa (PAC-1 binding) activation in vitro^[2].

体内研究
(In Vivo)

Cyproheptadine (1 mg/kg; i.p.; daily, for 5 days; C57BL/6 mice) exerts thromboprotective properties in vivo^[2].

Animal Model:	C57BL/6 mice (8-10 weeks old)^[2]
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection; daily, for 5 days
Result:	Prolonged occlusion times and tail bleeding times in mice.

Clinical Trial

分子量

287.40

Formula

C₂₁H₂₁N

CAS 号

129-03-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.