Quetiapine-d8 fumarate

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1185247-12-4

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议

产品名称

富马酸喹硫平 d8 (富马酸盐)

产品介绍

Quetiapine-d8 fumarate 是 Quetiapine hemifumarate 的氘代物。Quetiapine hemifumarate 是一种5-HT受体激动剂，对人5-HT1A的pEC₅₀值为 4.77。Quetiapine hemifumarate 是多巴胺受体 (dopamine receptor) 拮抗剂，对人D2的pIC₅₀值为 6.33。Quetiapine hemifumarate 对人D2，HT1A，5-HT2A，5-HT2C受体具有中高等亲和力，pK_i值为 7.25，5.74，7.54，5.55。具有抗抑郁和抗焦虑作用。

生物活性	Quetiapine-d8 fumarate is the deuterium labeled Quetiapine. Quetiapine is a5-HT receptorsagonist with apEC₅₀of 4.77 for human5-HT1A receptor. Quetiapine is adopamine receptorantagonist with apIC₅₀of 6.33 for humanD2 receptor. Quetiapine has moderate to high affinity for the humanD2,HT1A,5-HT2A,5-HT2C receptorwithpK_is of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].
分子量	507.63
Formula	C₂₅H₂₁D₈N₃O₆S
CAS 号	1185247-12-4
中文名称	富马酸喹硫平 d8 (富马酸盐)
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.