Oxyphenbutazone monohydrate

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

7081-38-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

羟布宗一水合物

产品介绍

Oxyphenbutazone monohydrate 是一种保泰松 (Phenylbutazone; HY-B0230) 代谢物，具有抗炎作用。Oxyphenbutazone monohydrate 是一种具有口服活性的非选择性COX抑制剂。Oxyphenbutazone monohydrate 能选择性地杀死不复制的结核分枝杆菌 (Mycobaterium tuberculosis)。

生物活性

Oxyphenbutazone monohydrate is aPhenylbutazone(HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone monohydrate is an orally active non-selectiveCOXinhibitor. Oxyphenbutazone monohydrate selectively kills non-replicatingMycobaterium tuberculosis^[1]^[2].

IC₅₀& Target

COX, Bacteria^[1]^[2]

体外研究
(In Vitro)

Oxyphenbutazone enhances the anticancer efficiency ofMethotrexate(MTX) (HY-14519) in Hep3B cells^[1].
Oxyphenbutazone (2.5-7.5 μM; 48 hours) co-treatment with (MTX, 0.25-1.0 μM) shows potential cytotoxicity against Hep3B cells^[1].
Oxyphenbutazone exhibits reparative effects in the hepatocytes^[1].

Cell Viability Assay^[1]

Cell Line:	Hep3B cells
Concentration:	2.5 μM, 5 μM, 7.5 μM
Incubation Time:	48 hours
Result:	Enhanced the cytotoxicity of MTX.

体内研究
(In Vivo)

Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.)^[1].

Animal Model:	Wistar strain albino male rats (5-6 weeks; 150-220 g)^[1]
Dosage:	70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week)
Administration:	PO; once a week; in two divided doses; for 13 weeks
Result:	Exerted potential anticancer activity in rats when co-treatment with MTX.

分子量

342.39

Formula

C₁₉H₂₂N₂O₄

CAS 号

7081-38-1

中文名称

羟布宗一水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.