(E)-Naringenin chalcone 是一种具有口服活性的抗过敏剂。(E)-Naringenin chalcone 还具有抗氧化、抗炎活性。(E)-Naringenin chalcone 可改善脂肪细胞的功能。(E)-Naringenin chalcone 可抑制大鼠腹膜肥大细胞的组胺的释放。
| 生物活性 | (E)-Naringenin chalcone is an orally active anti-allergic agent. (E)-Naringenin chalcone also has antioxidant, anti-inflammatory activities. (E)-Naringenin chalcone can improve adipocyte functions. (E)-Naringenin chalcone inhibits histamine release from rat peritoneal mast cell[1][2][4]. |
体外研究
(In Vitro) | (E)-Naringenin chalcone (25-125 μg/mL, 10 min) inhibits histamine release from rat peritoneal mast cells, with an IC50value of 68 μg/mL[1].
(E)-Naringenin chalcone (25-50 μM, 8 days) improves adipocyte (3T3-L1) functions by enhancing adiponectin production[2].
(E)-Naringenin chalcone (25-100 μM, 24 h) stimulates the activity of PPARγ in NIH-3T3 cells[2].
(E)-Naringenin chalcone (0-200 μM 24 h) inhibits the production of TNF-alpha, MCP-1, and nitric oxide (NO) by LPS-stimulated RAW 264 macrophages[4].
RT-PCR[2] | Cell Line: | 3T3-L1 adipocytes | | Concentration: | 25-100 μM | | Incubation Time: | 8 days | | Result: | Increased adiponectin mRNA levels up to 8.0-fold in a dose-dependent manner. |
Western Blot Analysis[4] | Cell Line: | RAW 264 macrophages | | Concentration: | 0,25, 50, 100, 200 μM | | Incubation Time: | 24 h | | Result: | Suppressed the degradation of IκB-α. |
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体内研究
(In Vivo) | (E)-Naringenin chalcone (0.8 mg/kg, oral administration) shows anti-allergic effect in type I allergic mice[1].
(E)-Naringenin chalcone (0.8 mg/kg, oral administration) suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells in allergic airway inflammatory mice[3].
| Animal Model: | Mouse type I allergic model[1] | | Dosage: | 0.8 mg/kg | | Administration: | Oral administration | | Result: | Inhibited the ear-swelling response, with the inhibitory ratio of 46.7%. |
| Animal Model: | Allergic airway inflammation induced in mice[3] | | Dosage: | 0.8 mg/kg | | Administration: | Oral administration, daily | | Result: | Decreased cell numbers of the infiltrating leukocyte and eosinophils.
Decreased Muc5ac and gob-5 expression in the lungs. |
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| 来源 | - Plants
- Solanaceae
- Lycopersicon esculentumMiller
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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