dencichine

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dencichine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

5302-45-4

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品名称

三七素
Dencichin
ODAP

产品介绍

Dencichin 是从三七中分到的非蛋白氨基酸，能够抑制HIF-prolyl hydroxylase-2 (PHD-2)的活性。

生物活性

Dencichin is a non-protein amino acid originally extracted fromPanax notoginseng, and can inhibitHIF-prolyl hydroxylase-2 (PHD-2)activity.

IC₅₀& Target

PHD-2^[1]

体外研究
(In Vitro)

Dencichin (β-ODAP, 10 μM, 50 μM, 100 μM and 200 μM) increases HRE expression by 1.3±0.09, 2.5±0.07, 4.2±0.15 and 1.3±0.07 fold respectively compared to control. Dencichin has intermolecular interactions with PHD-2^[1]. Dencichin (10 μM, 100 μM, 1 mM) significantly inhibits cell proliferation and extracellular matrix (ECM) proteins accumulation of HBZY-1 cells, and reduces the secretion of collagen I (Col I), collagen IV (Col IV), and fibronectin (FN)^[2].

体内研究
(In Vivo)

Dencichin improves metabolism disorder in diabetic nephropathy (DN) secondary to type II diabetes mellitus (DM) model. Dencichin (80, 160 mg/kg/day, p.o.) significantly prevents the up-regulation of TCH, TG, LDL, and HbAlc and the down-regulation of HDL in DN rats induced by STZ injection. Dencichin also attenuates renal injury induced in the DN secondary to type II DM model. Dencichin alleviates pancreas damage in the STZ-induced DN model. Dencichin regulates protein expression in the TGF-β/Smad signalling pathway in STZ-induced DN models^[2].

分子量

176.13

性状

Solid

Formula

C₅H₈N₂O₅

CAS 号

5302-45-4

中文名称

三七素

结构分类

Amino acids

来源

Plants
Araliaceae
Panax notoginseng

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

H₂O : 5 mg/mL(28.39 mM;Need ultrasonic)

DMSO : 5 mg/mL(28.39 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	5.6776 mL	28.3881 mL	56.7762 mL
5 mM	1.1355 mL	5.6776 mL	11.3552 mL
10 mM	0.5678 mL	2.8388 mL	5.6776 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。