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hCAI/II-IN-6
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
hCAI/II-IN-6图片
CAS NO:694466-00-7
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
hCAI/II-IN-6 是一种具有口服活性的human carbonic anhydrase(CA) 抑制剂。hCAI/II-IN-6 选择性地抑制 hCA II 和 hCA VII，对 hCA I，hCA II，hCA VII 和 hCA XII 的Ki值分别为 220，4.9，6.5 和 ＞50000 nM。hCAI/II-IN-6 在体内显示抗惊厥活性和抗最大电击 (MES) 活性。hCAI/II-IN-6 可以用于癫痫的研究。
生物活性

hCAI/II-IN-6 is an orally activehumancarbonic anhydrase(CA) inhibitor. hCAI/II-IN-6 selectively inhibits hCA II and hCA VII isoforms withKivalues of 220, 4.9, 6.5 and ＞50000 nM for hCA I, hCA II , hCA VII and hCA XII respectively. hCAI/II-IN-6 shows anticonvulsant activity and anti maximal electroshock (MES) activity in vivo. hCAI/II-IN-6 can be used for the research of epilepsy[1].

体外研究
(In Vitro)

hCAI/II-IN-6 (0-50 μM) inhibits hCA I, hCA II , hCA VII and hCA XII activities withKivalues of 220, 4.9, 6.5 and ＞50000 nM, respectively[1].

体内研究
(In Vivo)

hCAI/II-IN-6 (30-100mg/kg; i.p. once) shows good anticonvulsant effect in vivo[1].
hCAI/II-IN-6 (30 mg/kg; p.o. once) shows anti-MES activity in vivo[1].

Animal Model:Swiss albino mice[1]
Dosage:30 and 100 mg/kg
Administration:Intraperitoneal injection; 30-100 mg/kg once
Result:Provided seizure attenuation and good anticonvulsant effect, and showed an ED50of 13.7mg/kg in anticonvulsant quantification study.
Animal Model:Wistar albino rats[1]
Dosage:30 mg/kg
Administration:Oral gavage; 30 mg/kg once
Result:Showed anti-MES activity and significant protection from seizures up to 1h of drug administration and action was gone reduced after 1h.
分子量

388.48

性状

Solid

Formula

C19H24N4O3S

CAS 号

694466-00-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month