| CAS NO: | 58812-37-6 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 20mg | 电议 |
| Cas No. | 58812-37-6 |
| 别名 | 川楝素 |
| Canonical SMILES | C[C@@]1([C@H]2OC(C)=O)[C@@]3(O[C@@H]3C[C@H]1C4=COC=C4)[C@]5(C)[C@H](O)C[C@@]6([H])[C@]([C@@H](OC7)O)(C)[C@H](OC(C)=O)C[C@H](O)[C@]67[C@@]5([H])C2=O |
| 分子式 | C30H38O11 |
| 分子量 | 574.62 |
| 溶解度 | DMSO: 250 mg/mL (435.07 mM) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb et Zucc, possesses analgesic, insecticidal and anti-inflammatory activities[1]. Toosendanin (0.5 and 1 mg/kg, Intraperitoneal injection daily for 7 days) alleviates DSS-induced experimental colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling, and may provide a novel Chinese patent medicine for the treatment of murine colitis[1]. Animal Model: Forty-eight male C57BL/6 mice weighing 20-22 g[1]. [1]. Fan H, et al. Toosendanin alleviates dextran sulfate sodium-induced colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling. Int Immunopharmacol. 2019 Sep 11;76:105909. |
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