Fluphenazine decanoate dihydrochloride 是一种多巴胺D2受体抑制剂和吩噻嗪类精神安定剂 (neuroleptic)。Fluphenazine decanoate dihydrochloride可用于精神分裂症的研究。
| 生物活性 | Fluphenazine decanoate dihydrochloride is adopamineD2receptorinhibitor, is a long-acting phenothiazineneuroleptic. Fluphenazine can be used for schizophrenia research[1][2][3]. |
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体外研究
(In Vitro) | Fluphenazine decanoate dihydrochloride shows activity againstT. gondiiin human fibroblast cell cultures with an IC50value of 1.7 mM[1].
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体内研究
(In Vivo) | Fluphenazine decanoate dihydrochloride (0.22 mg/kg and followed by 0.33 mg/kg; i.m.; 8 times every 3 weeks), as an antipsychotic, increases sensitivity to dopamine on monkey model following extended treatment[2].
Fluphenazine decanoate dihydrochloride (25 mg/kg; i.m.; 6 times every 3 weeks; 24 weeks) induces mouth movements in the rat, serves as a pharmacological model of human tardive dyskinesia[3].
Fluphenazine decanoate dihydrochloride (1, 2, 3 mg/kg/d; s.c.; 60 d) shows antifertility effects and induces hyperprolactinemia concomitant with gonadotropin suppression in adult male rat[4].
| Animal Model: | Cebus apella monkey[2] | | Dosage: | 0.22 mg/kg and followed by 0.33 mg/kg | | Administration: | Intramuscular injection; 8 times per 3 weeks; 0.22 mg/kg for 63 weeks and 0.33 mg/kg for 6 weeks | | Result: | Decreased the aggressiveness composite behavioral variables (CBV).
Resulted stereotypic behavior induced by agonist and decreased prolactin response to AMPH. |
| Animal Model: | Male Sprague-Dawley rats (250 g)[3] | | Dosage: | 25 mg/kg | | Administration: | Intramuscular injection into the hind limb; 24 weeks | | Result: | Resulted in spontaneous vacuous chewing mouth movements and jaw tremor. |
| Animal Model: | Adult male rats[4] | | Dosage: | 1, 2, 3 mg/kg/d | | Administration: | Subcutaneous injection between 10:00-12:00 h; 60 days | | Result: | Increased serum prolactin level and suppressed serum LH and FSH levels at day 60.
Increased hypothalamic tyrosine hydroxylase levels, enhanced chromatin decondensation, and resulted DNA denaturation. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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