GR 82334 is a potent and specific reversibletachykininNK1receptorantagonist^[1]. GR 82334 inhibits substance P-induced sensitization by blocking SPNK1receptors in naked mole-rats^[1].

GR 82334 (intrathecal administration; 0.1 nmol-1 nmol) excites rats unnary bladder motihty at 1 nmol but not at 0.1 nmol, and the reflex chemonociceptive is reduced by the topical application of capsaicin (4 μg/50 ul)^[1].
GR 82334 (10 nM-1 μM; injected between vertebrae L4 and L5) has no effect at 10 nM in neither species, increases heat-induced foot withdrawal latency in mice at doses >100 nM, but no such increase in naked mole-rats, where doses >100 nM evoke a tendency for decreased latency^[2].

1386.55

C₆₉H₉₁N₁₅O₁₆

129623-01-4

{Glp}ADPNKFY-{Aaa}-LW-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.