CAS NO: | 141136-85-8 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1(PAR-1)agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds toPAR1tethered ligand and which can selectively mimic theactions ofthrombinvia this receptor[1][2]. |
IC50& Target | PAR-1[1] |
体外研究 (In Vitro) | Protease-Activated Receptor-1, PAR-1 Agonist induces activation of protein kinase C isoenzymes alpha and epsilon in human HT-29 colon carcinoma cells expressing PAR1 endogeneously. On the cellular level, Protease-Activated Receptor-1, PAR-1 Agonist and thrombin prompted HT-29 cell migration and matrix adhesion by a PKCepsilon-dependent mechanism as concluded because of the inhibition of PAR1-mediated effects by the PKC inhibitor bisindolylmaleimide I and the PKCepsilon translocation inhibitory peptide EAVSLKPT but not by the PKC inhibitor Go 6976[2]. |
分子量 | 762.90 |
Formula | C35H58N10O9 |
CAS 号 | 141136-85-8 |
Sequence | Thr-Phe-Leu-Leu-Arg-Asn |
Sequence Shortening | TFLLRN |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |