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Protease-Activated Receptor-1,PAR-1 Agonist
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Protease-Activated Receptor-1,PAR-1 Agonist图片
CAS NO:141136-85-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Protease-Activated Receptor-1, PAR-1 Agonist 是一种选择性蛋白酶激活受体1(PAR-1)激动肽。Protease-Activated Receptor-1, PAR-1 Agonist 对应于PAR1配体,可通过该受体选择性地模拟凝血酶的作用。
生物活性

Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1(PAR-1)agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds toPAR1tethered ligand and which can selectively mimic theactions ofthrombinvia this receptor[1][2].

IC50& Target

PAR-1[1]

体外研究
(In Vitro)

Protease-Activated Receptor-1, PAR-1 Agonist induces activation of protein kinase C isoenzymes alpha and epsilon in human HT-29 colon carcinoma cells expressing PAR1 endogeneously. On the cellular level, Protease-Activated Receptor-1, PAR-1 Agonist and thrombin prompted HT-29 cell migration and matrix adhesion by a PKCepsilon-dependent mechanism as concluded because of the inhibition of PAR1-mediated effects by the PKC inhibitor bisindolylmaleimide I and the PKCepsilon translocation inhibitory peptide EAVSLKPT but not by the PKC inhibitor Go 6976[2].

分子量

762.90

Formula

C35H58N10O9

CAS 号

141136-85-8

Sequence

Thr-Phe-Leu-Leu-Arg-Asn

Sequence Shortening

TFLLRN

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.