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TLR7 agonist 2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TLR7 agonist 2图片
CAS NO:1642857-69-9
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
TLR7 agonist 2 是一种有效且有选择性的 Toll 样受体 7 (TLR7) 激动剂,LEC值为 0.4 μM。
生物活性

TLR7 agonist2 is a potent and selectiveToll-like Receptor7(TLR7) agonist with aLECof 0.4 μM.

IC50& Target

LEC: 0.4 μM (TLR7)[1]

体外研究
(In Vitro)

TLR7 agonist 2 is a potent and selective Toll-like Receptor 7 (TLR7) agonist with a lowest effective concentration (LEC) of 0.4 μM in HEK293 cell. TLR7 agonist 2 is found to be selective for TLR7 over TLR8 with LEC of >100 μM for human TLR8. TLR7 agonist 2 demonstrates low inhibition across five CYP450 isozymes (IC50>10 μM) and is also not a time dependent inhibitor of CYP450 3A4. TLR7 agonist 2 has limited inhibition of the hERG potassium ion channel3H-dofetilide bindingin vitro(IC50>50 μM)[1].

体内研究
(In Vivo)

TLR7 agonist 2 is found to be rapidly cleared in conjunction with our target profile. Both Cmaxand AUC increase less than dose proportionally between 0.3 and 3 mg/kg and more than dose-proportionally between 3 and 10 mg/kg. TLR7 agonist 2 can induce an antiviral interferon stimulated gene (ISG) response without inducing an IFNα response at a low dose. TLR7 agonist 2 also induces a 2.7 log decrease in serum HBV viral load from 0.3 mg/kg, and a maximum 3.1 log decrease is observed for doses between 1 and 5 mg/kg[1].

分子量

336.35

性状

Solid

Formula

C17H16N6O2

CAS 号

1642857-69-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 160 mg/mL(475.69 mM;Need ultrasonic and warming)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.9731 mL14.8655 mL29.7309 mL
5 mM0.5946 mL2.9731 mL5.9462 mL
10 mM0.2973 mL1.4865 mL2.9731 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。