Norzopiclone is the inactive metabolite of Zopiclone. Norzopiclone has some anxiolytic properties.

The main urine metabolites of racemic zopiclone are the less active eszopiclone-N-oxide (RP 29753) and the inactive Norzopiclone (N-desmethyleszopiclone, RP 32273)^[1]. Zopiclone has two major metabolites, N-oxideZopiclone and Norzopiclone (N-desmethyl-Zopiclone). N-oxideZopiclone has a hypnotic activity lower than the parent Zopiclone, whereas Norzopiclone (N-desmethyl-Zopiclone) lacks hypnotic effect, but has some anxiolytic properties^[3].

A demethylation metabolic pathway produces Norzopiclone (N-desmethylzopiclone), a metabolite which reportedly accounts for 15% of an oral dose of racemic Zopiclone, and which is also reportedly inactive^[2]. N-oxide-Zopiclone has a similar t_1/2compared to parent Zopiclone, while the t_1/2of Norzopiclone (N-desmethyl-Zopiclone) ranges from 7 to 11 h^[3].

374.78

C₁₆H₁₅ClN₆O₃

59878-63-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.