您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Pyrantel
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Pyrantel
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pyrantel图片
CAS NO:15686-83-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Pyrantel 是一种口服有效的驱虫剂,也是烟碱乙酰胆碱受体 (nAChR) 激动剂。Pyrantel 可引起寄生虫的痉挛性肌肉麻痹。Pyrantel 可用于寄生虫感染的研究,比如蛔虫病、钩虫感染、肠虫病 (蛲虫感染)、毛霉菌病和旋毛虫病。
生物活性

Pyrantel is an orally active anthelmintic and an agonist of thenicotinic acetylcholine receptor(nAChR). Pyrantel can cause spasmodic muscle paralysis in parasites. Pyrantel can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis[1][2].

IC50& Target

Parasites[1][2].

体外研究
(In Vitro)

Pyrantel (10 nM-10 μM; 72 h) shows good anti-A. suumand (0-168.2 M; 72 h) anti-N. americanusactivity[1][2].

Cell Viability Assay[1]

Cell Line:A. suum
Concentration:10 nM-10 μM
Incubation Time:72 h
Result:InhibitedA. suumwith a pEC50value of 7.24.

Cell Viability Assay[2]

Cell Line:N. americanus
Concentration:0-168.2 M (0-100 μg/mL)
Incubation Time:72 h
Result:Inhibited third-stage larvae and adult ofN. americanuswith IC50values of 2.0 and 7.6 mg/mL, respectively.
体内研究
(In Vivo)

Pyrantel (10 mg/kg; p.o.; single) reduces the worms inA. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%[2].

Animal Model:Male Syrian Golden hamsters (3-week-old;A. ceylanicum-infected)[2].
Dosage:10 mg/kg
Administration:Oral administration; single.
Result:Exhibited worm burden reduction and worm expulsion rates of 87.2% and 63.4%, respectively.
Clinical Trial
分子量

206.31

Formula

C11H14N2S

CAS 号

15686-83-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.