CAS NO: | 5588-33-0 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Mesoridazine (TPS-23) , a metabolite ofThioridazine(HY-B0965A), acts as an orally active phenothiazineantipsychotic agent. Mesoridazine is a potent and rapid open-channel blocker ofhuman ether-a-go-go related gene (hERG)channels and blocks hERG currents with anIC50of 550 nM (at 0 mV) in human embryonic kidney 293 cells[1].Mesoridazine can be used for the research of schizophrenia, as well as certain other psychiatric disorders[1][2]. | ||||||||
IC50& Target | IC50: hERG currents[1] | ||||||||
体外研究 (In Vitro) | Mesoridazine blocks human ether-a-go-go-related gene (HERG) currents in a concentration-dependent manner (IC50= 550 nM at 0 mV), block increased significantly over the voltage range where HERG activates and saturates at voltages eliciting maximal HERG channel activation[1]. | ||||||||
体内研究 (In Vivo) | Mesoridazine (15 mM; topical administration; once or daily for 7 consecutive days) displays potent activity and a long period of analgesia at blocking cutaneous pain[3].
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分子量 | 386.57 | ||||||||
Formula | C21H26N2OS2 | ||||||||
CAS 号 | 5588-33-0 | ||||||||
中文名称 | 硫利达嗪EP杂质B | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |