您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Mesoridazine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Mesoridazine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mesoridazine图片
CAS NO:5588-33-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
TPS-23
产品介绍
Mesoridazine (TPS-23) 是硫唑嗪的活性代谢物,是一种具有口服的活性吩噻嗪类抗精神类疾病试剂。Mesoridazine 是一种有效、快速的人类醚-a-go-go 相关基因 (hERG) 通道的阻断剂,在 0 mV 时阻断人胚肾 293 细胞 hERG 电流的IC50为 550 nM。Mesoridazine 可用于精神分裂症以及某些其他精神疾病的研究。
生物活性

Mesoridazine (TPS-23) , a metabolite ofThioridazine(HY-B0965A), acts as an orally active phenothiazineantipsychotic agent. Mesoridazine is a potent and rapid open-channel blocker ofhuman ether-a-go-go related gene (hERG)channels and blocks hERG currents with anIC50of 550 nM (at 0 mV) in human embryonic kidney 293 cells[1].Mesoridazine can be used for the research of schizophrenia, as well as certain other psychiatric disorders[1][2].

IC50& Target

IC50: hERG currents[1]

体外研究
(In Vitro)

Mesoridazine blocks human ether-a-go-go-related gene (HERG) currents in a concentration-dependent manner (IC50= 550 nM at 0 mV), block increased significantly over the voltage range where HERG activates and saturates at voltages eliciting maximal HERG channel activation[1].
Mesoridazine (15 mM; 24 h) shows total absorption of 15.94 ± 4.04% and 39.24 ± 5.11% in nude mouse and pig skin, respectively[3].

体内研究
(In Vivo)

Mesoridazine (15 mM; topical administration; once or daily for 7 consecutive days) displays potent activity and a long period of analgesia at blocking cutaneous pain[3].
Mesoridazine (15 mM) shows intradermal concentration of 0.34 0.74 nmol/mg after topical application on nude mouse back for 6 h[3].

Animal Model:Eight-week-old female nude mice[3]
Dosage:15 mM
Administration:Topical administration, once (analgesia test) or daily for 7 consecutive days (irritation test)
Result:Showed analgesic effect. A slight transepidermal water loss (TEWL) increased from 7.8 to 9.9 g/m2/h was observed.
分子量

386.57

Formula

C21H26N2OS2

CAS 号

5588-33-0

中文名称

硫利达嗪EP杂质B

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.