4,9-Anhydrotetrodotoxin

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

13072-89-4

包装与价格：

产品名称

Anhydroepitetrodotoxin

产品介绍

4,9-Anhydrotetrodotoxin 是一种选择性的电压门控钠通道 (VGSC) 抑制剂，可阻断人脑中的 Nav1.1 和 Nav1.6，并且在失活的 Nav1.6 电压依赖性中诱导超极化偏移。

生物活性	4,9-Anhydrotetrodotoxin is a selective voltage-gatedsodium channel(VGSC) inhibitor that blocks Nav1.1 and Nav1.6 in human brain and induces a hyperpolarizing shift in the voltage dependence of inactivated Nav1.6^[1].
体外研究 (In Vitro)	4,9-Anhydrotetrodotoxin (0.01-10000 nM) results in significant blockade of Nav1.6-mediated Na current in the nanomolar range, it also has significant effects on Nav1.1-mediated Na current in human brain sample^[1].
分子量	301.25
Formula	C₁₁H₁₅N₃O₇
CAS 号	13072-89-4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.