CAS NO: | 1211866-85-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | TC-N 1752 is a potent and orally active inhibitor ofNav1.7, withIC50s of 0.17 μM, 0.3 μM, 0.4 μM, 1.1 μM and 2.2 μM athNav1.7,hNav1.3,hNav1.4,hNaV1.5andrNav1.8, respectively. TC-N 1752 also inhibits tetrodotoxin-sensitive sodium channels. TC-N 1752 shows analgesic efficacy in the Formalin model of pain[1][2][3]. | ||||||||||||||||
IC50& Target[1][2] |
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体外研究 (In Vitro) | TC-N 1752 (compound 52) state-dependently inhibits Nav1.7, with IC50of 170 nM on channels that are 20% inactivated and IC50of 3.6 μM on fully noninactivated channels[1]. | ||||||||||||||||
体内研究 (In Vivo) | TC-N 1752 (compound 52) (3-30 mg/kg; p.o.) dose-dependently shows analgesic effect in the Formalin model[1].
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分子量 | 516.52 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C25H27F3N6O3 | ||||||||||||||||
CAS 号 | 1211866-85-1 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 125 mg/mL(242.00 mM;Need ultrasonic) 配制储备液
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