CAS NO: | 73069-14-4 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | Atractylenolide II is a sesquiterpene compound isolated from the dried rhizome ofAtractylodes macrocephala(Baizhu in Chinese); anti-proliferative activity. IC50 value: 82.3 μM(B16 melanoma cell, 48 h) [1] Target: anticancer natural compound in vitro: AT-II treatment for 48 h dose-dependently inhibited cell proliferation with an IC(50) of 82.3 μM, and induced G1 phase cell cycle arrest. Moreover, treatment with 75 μM AT-II inducedapoptosis. These observations were associated with the decrease of the expression ofCdk2, phosphorylated-Akt, phosphorylated-ERK andBcl-2, the increase of the expression of phosphorylated-p38, phosphorylated-p53, p21, p27, and activation of caspases-8, -9 and -3. In addition, a chemical inhibitor of p53, PFTα, significantly decreased AT-II-mediated growth inhibition andapoptosis[1]. In B16 and A375 cells, AT-II (20, 40 μm) treatment for 48 h dose-dependently reduced protein expression levels of phospho-STAT3, phospho-Src, as well as STAT3-regulatedMcl-1andBcl-xL. Overexpression of a constitutively active variant ofSTAT3, STAT3C in A375 cells diminished the antiproliferative and apoptotic effects of AT-II [2]. in vivo: Daily administration of AT-II (12.5, 25 mg/kg, i.g.) for 14 days significantly inhibited tumor growth in a B16 xenograft mouse model and inhibited the activation/phosphorylation ofSTAT3andSrcin the xenografts [2]. | ||||||||||||||||
分子量 | 232.32 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C15H20O2 | ||||||||||||||||
CAS 号 | 73069-14-4 | ||||||||||||||||
中文名称 | 白术内酯 II | ||||||||||||||||
结构分类 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(430.44 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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