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Longistyline A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Longistyline A图片
CAS NO:64095-60-9
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Longistylin A
产品介绍
Longistyline A (Longistylin A) 是一种天然二苯乙烯，可从木豆中提取。Longistyline A 对耐甲氧西林金黄色葡萄球菌具有抑菌效应，MIC值为 1.56 μg/mL。Longistyline A 具有神经保护作用，可用于感染和神经系统疾病的研究。
生物活性

Longistyline A (Longistylin A) is a natural stilbene, it can be isolated from leaves ofCajanus cajan. Longistyline A shows antimicrobial activity againstMRSAwith anMICvalue of 1.56 μg/mL. Longistyline A shows neuroprotective effects, it can be used for the research ofinfectionand nerve diseases[1][2].

IC50& Target

IC50: 8.61 μg/mL (murine RAW264.7 cells)[2]

体外研究
(In Vitro)

Longistyline A (4-16 μM/L; 48 h) reduces the corticosterone-induced neurotoxicity in PC12 cells[1].
Longistyline A can function as a membrane-targeting antibacterial agent by disturbing bacterial membrane potential and increasing the permeation[2].
Longistyline A (0-100 μg/mL) shows significant antimicrobial activity against tested Gram-positive bacteria, such as B.cereus CMCC63302 with MIC values of 25 μg/mL, S.aureus CMCC26003 with MIC values of 1.56 μg/mL, and both two strains of MRSA (JCSC4744 and JCSC4469) with MIC values of 1.56 μg/mL[2].
Longistyline A (24 h) shows cytotoxicity towards murine RAW264.7 cells with an IC50value of 8.61 μg/mL[2].

Cell Cytotoxicity Assay[1]

Cell Line:PC12 cell line
Concentration:4, 8 and 16 μM/L
Incubation Time:48 hours
Result:Generated a neuroprotective effect against corticosterone-induced neurotoxicity in PC12 cells possibly by decreasing [Ca2+]i and caspase-3 activity.
体内研究
(In Vivo)

Longistyline A (10 μg dissolved in 50 μL PBS buffer; apply to the wound; for 30 min) improves wound healing, decreases MRSA bacterial survivals in the lesions and reduces inflammatory reaction in MRSA infected mice[2].

Animal Model:Female wound healing BALB/c mice with MRSA infection[2]
Dosage:10 μg
Administration:Apply to the wound; 10 μg dissolved in 50 μL PBS buffer; 5 min after infection for 30 min
Result:Showed a wound healing efficiency and significantly alleviated weight loss induced by MRSA infection. Reduced gram-positive microorganisms in vivo with a better effect than vancomycin. Reduced accumulation of immune cells at the injury site and alleviated induction of TNF-α and IL-6 in serum.
分子量

294.39

Formula

C20H22O2

CAS 号

64095-60-9

结构分类
  • Phenols
  • Monophenols
来源
  • Plants
  • Leguminosae
  • Cajanus cajan(L.) Millsp.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.