| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 25mg | 电议 |
| 100mg | 电议 |
| 500mg | 电议 |
Animal models | Male Lister Hooded rats model; |
Dosage form | 3, and 10 mg/kg; intraperitoneal injection; for 90 min; or 4 mg, oral administration |
Applications | Biperiden HCl acted as cognition impairer in rats and Biperiden (10 mg/kg) induced side-effects, with rats taking more time to start the task [1]. Moreover, oral doses of 4 mg of Biperiden HCl reached a Cmax of approximately 4 ng/mL [2]. |
Other notes | Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
| 产品描述 | Biperiden HCl is an anticholinergic drug [1]. As an anticholinergic drug, biperiden is first used in the treatment of Parkinson's disease. It is a competitive antagonist of muscarinic receptor. It has been believed that in the patients of PD, a reduction of intranigral dopamine concentrations results in a relative imbalance between the dopaminergic and cholinergic neurological pathways. The anticholinergics can correct the imbalance through reducing the degree of neurotransmission mediated by neostriatal acetylcholine. Biperiden is also used to treat extrapyramidal side effects of antipsychotic drugs. In addition, the misuse of biperiden causing delirium has been reported in several clinical settings [1, 2]. References: |
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