PRATENSEIN

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PRATENSEIN

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2284-31-3

包装与价格：

包装	价格(元)
1mg	电议
2mg	电议
5mg	电议
10mg	电议

产品介绍

Pratensein 是一种黄酮类化合物，通过减少氧化损伤和恢复突触和 BDNF 水平来改善 β-淀粉样蛋白诱导的大鼠认知障碍。

生物活性

Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels^[1].

体内研究
(In Vivo)

Pratensein significantly attenuates neuronal degeneration and apoptosis in hippocampus. The over-expression in IL-1β and TNF-α as well as the extensive astrogliosis and microgliosis in hippocampus induced by Aβ1-42 are significantly reduced following administration of Pratensein. Pratensein treatment significantly suppresses the activation of NF-κB in hippocampus. Pratensein is able to increase the levels of synaptophysin and brain-derived neurotrophic factor (BDNF)^[1].
Pratensein (20 mg/kg; p.o.; once daily for 3 weeks) ameliorates learning and memory deficits in Aβ1-42 rat model of Alzheimer’s disease^[1].

Animal Model:	Male 10-week old Wistar rats^[1]
Dosage:	20 mg/kg
Administration:	P.o.; once daily for 3 weeks
Result:	The spatial learning and memory ability of rats was improved.

分子量

300.26

性状

Solid

Formula

C₁₆H₁₂O₆

CAS 号

2284-31-3

结构分类

Flavonoids
Isoflavones

Phenols
Polyphenols

来源

Plants
Leguminosae
Trifolium pratenseL.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

DMSO : 50 mg/mL(166.52 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.3304 mL	16.6522 mL	33.3045 mL
5 mM	0.6661 mL	3.3304 mL	6.6609 mL
10 mM	0.3330 mL	1.6652 mL	3.3304 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。