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Galegine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Galegine hydrochloride图片
CAS NO:2368870-39-5
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Galegine hydrochloride, 一种胍衍生物,有助于小鼠减轻体重。胍类是从G. officinalis中提取的化合物,产生双胍、二甲双胍和苯甲双胍。Galegine hydrochloride 激活 3T3-L1 脂肪细胞、L6 肌管、H4IIE 大鼠肝癌和 HEK293 人肾细胞系中的AMPK。Galegine hydrochloride 具有抗菌活性,对金黄色葡萄球菌菌株 (Staphylococcus aureus) 的最低抑菌浓度为 4 mg/L。
生物活性

Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived fromG. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activatesAMPKin 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride hasantibacterialactivity, with minimum inhibitory concentration of 4 mg/L againstStaphylococcus aureusstrains[1][2].

体外研究
(In Vitro)

Pre-treatment with Galegine hydrochloride (10 μM-3 mM; 5 h) produces a concentration-dependent stimulation of insulin-independent glucose uptake by 3T3-L1 adipocytes without any effect on cell viability. Incubation with Galegine hydrochloride (1 μM-1 mM, 5 h) produces a concentration-dependent stimulation of glucose uptake into L6 myotubes, again without any effect on cell viability[1].
Galegine hydrochloride (0.3-300 μM; 24 hours) produced a slight reduction in basal glycerol release and a more marked reduction in isoprenaline-stimulated glycerol release from 3T3-L1 adipocytes. Incubation of H4IIE rat hepatoma cells with Galegine hydrochloride (10 or 300 μM) for up to 6 hours produces a time-dependent activation of AMPK measured in cell lysates, with maximal activation at 360 min and twofold activation still evident at 24 hous in the presence of 300 μM Galegine hydrochloride. The effect of 300 ΜM Galegine hydrochloride is markedly greater than that of 10 μM. Incubation with Galegine hydrochloride for 1 hour produces a concentration-dependent activation of AMPK in both 3T3L-1 adipocytes and L-6 myotubes. Galegine hydrochloride also produces a concentration-dependent activation of the enzyme in a human kidney cell line (HEK293)[1].

体内研究
(In Vivo)

Galegine hydrochloride (63 mg/kg; feed; daily for 11 days) produces a significant reduction in body weight[1].

Animal Model:Adult male BALB/c mice[1]
Dosage:63 mg/kg
Administration:feed; daily for 11 days
Result:Produced a significant reduction in body weight.
分子量

163.65

Formula

C6H14ClN3

CAS 号

2368870-39-5

结构分类
  • Alkaloids
  • Other Alkaloids
来源
  • Plants
  • Leguminosae
  • Galega officinalisLinn.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro: 

H2O : 43.33 mg/mL(264.77 mM;Need ultrasonic)

DMSO : 5.2 mg/mL(31.78 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM6.1106 mL30.5530 mL61.1060 mL
5 mM1.2221 mL6.1106 mL12.2212 mL
10 mM0.6111 mL3.0553 mL6.1106 mL