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Voacangine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Voacangine图片
CAS NO:510-22-5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Cas No.510-22-5
别名伏康京碱
化学名12-methoxy-ibogamine-18-carboxylic acid, methyl ester
Canonical SMILES[H][C@]12[C@@H](CC)C[C@]3([H])C[C@@]1(C(OC)=O)C4=C(C(C=C(OC)C=C5)=C5N4)CC[N@]2C3
分子式C22H28N2O3
分子量368.5
溶解度DMF: 16 mg/ml,DMSO: 16 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.33 mg/ml
储存条件Store at -20°C,protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 Voacangine is an indole alkaloid that has been found in T. citrifolia, V. africana, V. obtusa, and T. iboga with diverse biological activities. It inhibits the growth of M. tuberculosis, M. avium, and M. kansasii with MIC values of 50, >200, and 100 μg/mL, respectively. Voacangine (0.01-100 μM) dose-dependently reduces membrane currents in HEK293 cells expressing the hERG potassium channel and displaces the hERG ligand dofetilide with a Ki value of 3.9 μM. Voacangine suppresses agonist-induced activation of transient receptor potential (TRP) channels with IC50 values of 50 and 9 μM for activation induced by the TRPV1 agonist capsaicin and the TRPM8 agonist menthol, respectively. It also activates TRPA1 channels and stimulates calcium influx (IC50 = 8 μM in HEK293 cells expressing TRPA1), an effect that is blocked by the TRPA1 blocker HC-030031 . In vivo, voacangine (2 and 4 μg per egg) inhibits angiogenesis in chick embryo chorioallantoic membranes without apparent cytotoxicity.